SBlogI entrevista:
Dr. Leonardo V. Riella
Harvard Medical School, EUA
Riella, L. V. - Novel role of the Notch pathway in graft rejection.
SBlogI - What is the main finding or conclusion that will be emphasized?
Riella, L. V. - Different
Notch signals are able to drive complete opposite alloimmune responses
in the transplant setting, leading to either rejection or improvement in
graft survival.
SBlogI - What is the significance of this finding?
Riella, L. V. - Targeting the Notch pathway has a great promise for immunomodulation of the immune response.
SBlogI - What are the future perspectives in this area?
Riella, L. V. - Improvement
of monoclonal antibodies and inhibitory drugs will advance the field in
multiple areas, including oncology, transplantation and infectious
disease.
SBlogI - What are the challenges in this area? Are there controversies? Opponent hypotheses?
Riella, L. V. - Challenges
are related to the broad expression of the Notch pathway in multiple
tissues, requiring the development of more selective agents to avoid
toxicity.
SBlogI - Any suggestions for background reading?
Riella, L. V. -
Amsen et al. The different faces of Notch in T-helper-cell differentiation. Nat Rev Immunol 2009;0(2):116-124.
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