On the cover: T cell subpopulations are defined by specific phenotypic markers (such as CD molecules), functions (such as secreted cytokines), or expression of specific transcription factors. Ohkura et al. (785–799) propose a definition of Treg cells on the basis of specific intracellular information, i.e., epigenetic pattern and transcription-factor expression. The cover image depicts the concept that important factors defining Treg cell lineage are not appearance (drawing of the image) but internal pattern of epigenetics and transcription factors (painting pattern). Art by Naganari Ohkura.
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