Regulação negativa dos TLRs

Colegas,
indico aqui uma ótima revisão para quem gosta de imunidade inata - regulação negativa dos TLRs, na última edição da Trends in Immunology
Abraços, Tiago.

Trends in Immunology, Volume 33, Issue 9, 449-458, 20 June 2012

doi:10.1016/j.it.2012.05.002

Review

Dissecting negative regulation of Toll-like receptor signaling

Takeshi Kondo^1, 2, Taro Kawai^1, 2 and Shizuo Akira^1, 2,  

¹ Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan
² Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan

Abstract

Toll-like receptors (TLRs) sense invading microbial pathogens and play crucial roles in the activation of innate and adaptive immunity. However, excessive TLR activation can disrupt immune homeostasis, and may be responsible for the development of autoimmune and inflammatory diseases. As such, the molecules and pathways that negatively control TLR signaling have been intensively investigated. Here, we discuss recent insights into the negative regulation of TLR signaling, with focus on three major mechanisms: (i) dissociation of adaptor complexes; (ii) degradation of signal proteins; and (iii) transcriptional regulation. We also highlight how pathogens negatively target TLR signaling as a strategy to evade the host immune response.